Activation and Detoxification of N-2-fluorenylacetamide in Man.

Five patients with various malignant diseases excreted rapidly, chiefly in the urine, isotope from a single oral tracer dose of ./V-2-fluorenyl-9-C14-acetamide. The urine con tained 24-30 per cent of the dose of the detoxification product, ^-(T-hydroxy^-fluorenyl)acetamide, as the glucuronic acid conjugate. The other major metabolite was Af-hydroxy-2-fluorenylacetamide, a proximate carcinogen derived from the com pound administered. The amount of this compound varied from 4.4 to 13 per cent of the dose.